Steroid 12-alpha-Hydroxylase

A liver microsomal cytochrome P450 enzyme that catalyzes the 12-alpha-hydroxylation of a broad spectrum of sterols in the presence of molecular oxygen and NADPH-FERRIHEMOPROTEIN REDUCTASE. This enzyme, encoded by CYP8B1gene, converts 7-alpha-hydroxy-4-cholesten-3-one to 7-alpha-12-alpha-dihydroxy-4-cholesten-3-one and is required in the synthesis of BILE ACIDS from cholesterol.

Also Known As:

CYP8B1; 12alpha-Hydroxylase; Cytochrome P450 8B1; Cytochrome P450 CYP8B1; Steroid 12-Hydroxylase; Steroid-12-Hydroxylase; Steroid-12-Monooxygenase; Sterol 12 alpha-Hydroxylase; 12 alpha Hydroxylase; 12 alpha-Hydroxylase, Sterol; 12alpha Hydroxylase; Steroid 12 Hydroxylase; Steroid 12 Monooxygenase; Steroid 12 alpha Hydroxylase; Sterol 12 alpha Hydroxylase; alpha-Hydroxylase, Sterol 12; 12-alpha-Hydroxylase; Steroid 12-Monooxygenase; Sterol 12-alpha-Hydroxylase; Steroid, hydrogen-donor:oxygen oxidoreductase (12-alpha-hydroxylating)

Enzymes and Coenzymes: 1
- Enzymes: 152586
  - Oxidoreductases: 13671
    - Oxygenases: 333
      - Mixed Function Oxygenases: 2175
        Cytochrome P-450 Enzyme System: 5365
        Steroid Hydroxylases: 11
        Steroid 12-alpha-Hydroxylase: 55
        Cytochrome P450 Family 8
        Steroid 12-alpha-Hydroxylase: 55
- Cytochromes: 2196
  - Cytochrome P-450 Enzyme System: 5365
    - Steroid Hydroxylases: 11
      - Steroid 12-alpha-Hydroxylase: 55
    - Cytochrome P450 Family 8
      - Steroid 12-alpha-Hydroxylase: 55
Amino Acids, Peptides, and Proteins: 1
- Proteins: 484843
  - Hemeproteins: 194
    - Cytochromes: 2196
      - Cytochrome P-450 Enzyme System: 5365
        Steroid Hydroxylases: 11
        Steroid 12-alpha-Hydroxylase: 55
        Cytochrome P450 Family 8
        Steroid 12-alpha-Hydroxylase: 55

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Drug/Important Bio-Agent (IBA)